(4-Hydroxy-2-(trifluoromethyl)phenyl)boronic acid

(4-Hydroxy-2-(trifluoromethyl)phenyl)boronic acid - Names and Identifiers

Name	4-Hydroxy-2-(trifluoromethyl)phenylboronic acid
Synonyms	4-HYDROXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID 4-Hydroxy-2-(trifluoromethyl)phenylboronic acid 4-Hydroxy-2-(trifluoromethyl)benzeneboronic acid 4-Hydroxy-2-(trifluoromethyl) phenyl boronic acid (4-Hydroxy-2-(trifluoromethyl)phenyl)boronic acid Boronic acid, B-[4-hydroxy-2-(trifluoromethyl)phenyl]-
CAS	943918-05-6

(4-Hydroxy-2-(trifluoromethyl)phenyl)boronic acid - Physico-chemical Properties

Molecular Formula	C7H6BF3O3
Molar Mass	205.93
Density	1.50±0.1 g/cm3(Predicted)
Boling Point	354.5±52.0 °C(Predicted)
pKa	8.66±0.31(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

(4-Hydroxy-2-(trifluoromethyl)phenyl)boronic acid - Introduction

4-Hydroxy-2-(trifluoromethyl)phenylboronic acid is an organic compound with the chemical formula C7H6BF3O2.

Nature:
-Appearance: Colorless to slightly yellow crystal
-melting point: 145-148 ℃
-Molecular weight: 195.94
-Solubility: Soluble in polar organic solvents such as ethanol, dimethylformamide and dichloromethane

Use:
4-Hydroxy-2-(trifluoromethyl)phenylboronic acid can be used as an important reagent in organic synthesis, and has a wide range of applications in drug synthesis, pesticide synthesis and material chemistry. It is one of the effective reagents for Suzuki-Miyaura cross-coupling reactions and can be used to construct carbon-carbon bonds. In addition, it can also be used to prepare a variety of functional organic compounds, such as phenolic resins, boron-containing polymers, molecular probes, etc.

Method:
The preparation of 4-Hydroxy-2-(trifluoromethyl)phenylboronic acid is generally obtained by the reaction of phenylboronic acid and trifluoroformic acid. The specific reaction equation is as follows:
C6H5BF3O HCO2H → C7H6BF3O2 H2O

Safety Information:
4-Hydroxy-2-(trifluoromethyl)phenylboronic acid is generally considered to be relatively safe under routine experimental conditions. However, general laboratory procedures should still be followed to avoid skin contact and inhalation. If accidental contact or inhalation, should immediately rinse with water, and medical treatment.

Last Update：2024-04-09 20:52:54